King’s Rest - The mini bosses following the Golden Serpent (Queen Patlaa, Queen Wasi, King Rahu’ai and King A’akul) are all scary without buffs, so giving them more health and damage makes this room uncomfortable at best. Spectral Berserkers leave a nasty physical DoT on the tank that stacks, and it can quickly get out of control on Fortified weeks. Watch out for Spectral Beastmaster’s Poison Barrage as it can easily wipe a group if it hits multiple party members. Shadow of Zul will deal a lot of damage to the tank, so make sure to have cooldowns ready.
Waycrest Manor - The Heartsbane witches and Bewitched Captains do tremendous damage to the tank, and the Matrons have a lot of health. The confined quarters of the manor don’t leave much room for kiting, either. The Gloom Horrors before the final boss do a lot of damage when they jump, so you will want to be careful about which party member is standing furthest out (which is what determines who gets leapt on).
The Underrot - You will want to handle Tick packs carefully as they can easily wipe a group if they all explode simultaneously. Be careful on packs with Headhunters (who root) and Blood Matrons (who charge and cleave) as you can get one-shot by this combination. Bloodswarmers will be at the very least incredibly annoying and potentially lethal if their Sonic Scream interrupts healers. Pay very close attention to the Spirit Drain Totem from Bloodsworn Defilers. Fetid Maggot’s Rotten Bile can quickly kill a ranged player if it isn’t interrupted.
The MOTHERLODE!!! - Be sure to interrupt Hired Assassins as their Toxic Blades / Hail of Flechettes combo can easily wipe a group. Mine Rats target random players with Throw Rock, so be careful not to pull too many and risk bad RNG on who gets targeted. Taskmaster Askari wrecks tanks, so make sure to have cooldowns ready for him. Watch out for Mastermind’s Energy Lash as it hurts quite a bit, and don’t let Feckless Assistants finish their Transfiguration Serum cast or they will turn into Grotesque Experiments which are much more difficult. Be vigilant with Crawler Mines on the way to Mogul as they will do quite a bit of damage if they explode on a player.